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Sorafenib is a cancer medication that interferes with the growth and spread of cancer cells in the body. Sorafenib is used to treat liver cancer, thyroid cancer, or a type of kidney cancer called advanced renal cell carcinoma.
Sorafenib may also be used for purposes not listed in this medication guide.
You should not use sorafenib if you are allergic to it, or if you have squamous cell lung cancer and you are being treated with carboplatin (Paraplatin) and paclitaxel (Onxol, Taxol, Abraxane).
To make sure sorafenib is safe for you, tell your doctor if you have:
Do not use sorafenib if you are pregnant. It could harm the unborn baby.
Use birth control to prevent pregnancy while you are receiving sorafenib, whether you are a man or a woman. Tell your doctor right away if a pregnancy occurs while either parent is taking this medication. Keep using birth control for at least 2 weeks after your treatment ends.
It is not known whether sorafenib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.
Sorafenib is usually taken 2 times per day. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Take sorafenib on an empty stomach, at least 1 hour before or 2 hours after eating.
Do not crush, chew, or break a sorafenib tablet. Swallow it whole with water. Your blood pressure will need to be checked often. If you need surgery or dental work, tell the surgeon or dentist ahead of time that you are using sorafenib. You may need to stop using the medicine for a short time.
Take the missed dose as soon as you remember, but at least 2 hours since your last meal. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Tell your doctor about all other cancer medicines you use, especially cisplatin, cyclophosphamide, docetaxel, doxorubicin, fluorouracil, gemcitabine, irinotecan, paclitaxel, or tamoxifen.
Many drugs can interact with sorafenib. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with sorafenib, especially:
This list is not complete and many other drugs can interact with sorafenib. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Stop using sorafenib and call your doctor at once if you have:
Common side effects may include:
This is not a complete list of side effects and others may occur.
This medicine can pass into body fluids (urine, feces, vomit). Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.
Store at room temperature away from moisture, heat, and light.